There is a considerable interest in detailed study of free radical-mediated damage to biological systems due to pesticide exposure. These Compounds have induced an excessive production of free radicals which are responsible for several cell alterations in the organism. Recent investigations have proved the crucial role of nutritional antioxidants to prevent the damage caused by toxic compounds. Dimethoate (DM) is an organ phosphorous insecticide and acaricide used to kill mites and aphids among other insects and is applied on citrus, cotton, fruit, olives, potatoes, tea, tobacco and vegetables. The aim of the present work was to study biochemical changes that might occur in the kidney of albino rats as a result of DM intoxication. In the present investigation the animals were kidney treated with th 1/10 of LD of DM via oral gavage (34.5mg/kg body weight.