Submandibular gland is rich source of epidermal growth factor (EGF). To investigate the role of salivary EGF on the development of male reproductive system we have performed the sialoadenectomy (removal of submandibular glands) of the 20 days old male mice and this sialoadenectomised mice was sacrificed on 45, 60 and 90th day. The testis, seminal vesicle, prostate gland, caput and cauda epididymis were dissected out for protein estimation and histological studies.